Blar i forfatter "Majonga, Edith D."

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    • Carotid intima media thickness in older childrenand adolescents with HIV taking antiretroviraltherapy 

      Majonga, Edith D.; Chiesa, Scott T.; McHough, Grace; Mujuru, Hilda; Nathoo, Kusum; Odland, Jon Øyvind; Kaski, Juan Pablo; Ferrand, Rashida A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-04)
      Increased carotid intima-media thickness (cIMT) is reported in both adults and children with human immunodeficiency virus (HIV) in high income settings and is associated with an increased risk of cardiovascular disease, but data from sub-Saharan Africa is lacking.<p> <p>We assessed cIMT using ultrasound in perinatally HIV-infected children aged 6 to 16 years taking antiretroviral therapy (ART) ...

    • Echocardiographic reference ranges in older children and adolescents in sub-Saharan Africa 

      Majonga, Edith D.; Rehman, Andrea M.; McHugh, Grace; Mujuru, Hilda A.; Nathoo, Kusum; Patel, Mohammad S.; Munyati, Shungu; Odland, Jon Øyvind; Kranzer, Katharina; Kaski, Juan P.; Ferrand, Rashida A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-06-30)
      Background: Echocardiographic reference ranges are important to identify abnormalities of cardiac dimensions. Reference ranges for children in sub-Saharan Africa have not been established. The aim of this study was to establish echocardiographic z-score references for Black children in sub-Saharan Africa.<p> <p>Methods: 282 healthy subjects aged 6–16 years (143 [51%] males) with no known history ...

    • The effect of azithromycin for management of HIV-associated chronic lung disease on right heart function: Results from the BREATHE trial 

      Majonga, Edith D.; Mapurisa, Gugulethu Newton; Rehman, Andrea M.; McHugh, Grace; Bandason, Tsitsi; Mujuru, Hilda; Gonzalez-Martinez, Carmen; Odland, Jon O.; Kennedy, Neil; Ferrand, Rashida A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-11-20)
      Background - Right heart abnormalities and pulmonary hypertension (PH) may be secondary to chronic lung disease. Chronic lung disease is common in children with HIV. In the BREATHE trial (Trial registration: NCT02426112), azithromycin (AZM) reduced the risk of acute respiratory exacerbations in children aged 6–19 years with HIV-associated chronic lung disease (HCLD) taking antiretroviral therapy. ...

    • Effect of Once-Weekly Azithromycin vs Placebo in Children With HIV-Associated Chronic Lung Disease: The BREATHE Randomized Clinical Trial 

      Ferrand, Rashida A.; McHugh, Grace; Rehman, Andrea M.; Mujuru, Hilda A.; Simms, Victoria; Majonga, Edith D.; Nicol, Mark P.; Flægstad, Trond; Gutteberg, Tore Jarl; Gonzalez-Martinez, carmen; Corbett, Elizabeth L.; Rowland-Jones, Sarah; Kranzer, Katharina; Weiss, Helen Anne; Odland, Jon Øyvind (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-12-17)
      <i>Importance</i> - HIV-associated chronic lung disease (HCLD) in children is associated with small airways disease, is common despite antiretroviral therapy (ART), and is associated with substantial morbidity. Azithromycin has antibiotic and immunomodulatory activity and may be effective in treating HCLD through reducing respiratory tract infections and inflammation.<p> <p><i>Objective</i> - ...

    • High prevalence of echocardiographic abnormalities in older HIV-infected children taking antiretroviral therapy 

      Majonga, Edith D.; Rehman, Andrea M.; Simms, Victoria; McHugh, Grace; Mujuru, Hilda A.; Nathoo, Kusum; Odland, Jon Øyvind; Patel, Mohammad S.; Kaski, Juan P.; Ferrand, Rashida A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-11-28)
      Background: Antiretroviral therapy (ART) has decreased mortality so that increasing numbers of children with HIV are reaching adolescence. However, longstanding HIV infection and/or its treatment in children is associated with noninfectious complications including cardiac disease. We investigated the prevalence, spectrum and risk factors for echocardiographic abnormalities among children established ...

    • History of tuberculosis is associated with lower exhaled nitric oxide levels in HIV-infected children 

      Sovershaeva, Evgeniya; Kranzer, Katharina; McHugh, Grace; Bandason, Tsitsi; Majonga, Edith D.; Usmani, Omar S.; Rowland-Jones, Sarah; Gutteberg, Tore Jarl; Flægstad, Trond; Ferrand, Rashida A.; Odland, Jon Øyvind (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-09-01)
      <p><i>Objective - </i>HIV disrupts host defense mechanisms and maintains chronic inflammation in the lung. Nitric oxide is a marker of lung inflammation and can be measured in the exhaled air. We investigated the relationship between exhaled nitric oxide (eNO), HIV status and airway abnormalities in perinatally HIV-infected children aged 6–19 years. <p><i>Design - </i>A cross-sectional study. <p ...

    • Racial Variation in Echocardiographic Reference Ranges for Left Chamber Dimensions in Children and Adolescents: A Systematic Review 

      Majonga, Edith D.; Norrish, Gabrielle; Rehman, Andrea M.; Kranzer, Katharina; Mujuru, Hilda A.; Nathoo, Kusum; Odland, Jon Øyvind; Kaski, Juan P.; Ferrand, Rashida A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-04-04)
      Abstract Echocardiography plays a critical role in the assessment of cardiac disease. Important differences in echocardiographically derived cardiac chamber dimensions have been previously highlighted in different population groups in adult studies, but this has not been systematically studied in children, whose body size changes throughout childhood. The aim of this study was to review the ...